Role of Harmful Molecules in the Pathogenesis of Sepsis: A Review

Marianne Frieri, Bethel Shiferaw, Krishan Kumar, Anthony Boutin

Division of Allergy Immunology, Department of Medicine, Department of Emergency Medicine, Nassau University Medical Center, NY, USA


Sepsis, a common condition encountered in hospital environments and remains an important cause of death at intensive care units. There are many factors such as genetics, physical agents, mediators and effectors involved in the development of sepsis.  A marked increase in serum procalcitonin during the course of a septic process often indicates an exacerbation of the illness, and a decreasing level is a sign of improvement. The patient’s immune surveillance could fail to eliminate the pathogen, allowing it to spread and there is a pro-inflammatory mediator release with, inappropriate activation. Journal of Nature and Science, 1(8):e142, 2015.



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