Histone acetyltransferase KAT8 and oocyte development

Shi Yin, Xiaohua Jiang, Tej K. Pandita, Qinghua Shi

College of Life Science and Technology, Southwest University for Nationalities, Chengdu, China. Molecular and Cell Genetics Laboratory, The CAS Key Laboratory of Innate Immunity and Chronic Diseases, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China, Collaborative Innovation Center of Genetics and Development, Collaborative Innovation Center for Cancer Medicine, Hefei ,China. Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, TX 77030, USA

Oocyte development is necessary for female fertility and is characterized by dramatic changes in gene expression and chromatin structure. Histone acetylation is an important epigenetic mechanism for gene regulation as it changes the chromatin structure and affects the binding ability of  transcription factors to DNAs. Histone acetylation level is regulated antagonistically by two classes of enzyme, histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this review, we briefly summarize the current knowledge about an important HAT, K (Lysine) Acetyltransferase 8 (KAT8), and introduce the role of this enzyme in oocyte and follicle development, which gives new insight about epigenetic and female reproduction. Journal of Nature and Science (JNSCI), 3(12):e476, 2017

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